Baltimore Orioles vs. Cleveland Guardians

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On April 16, 2026, Sports Illustrated published a for a 10-game MLB slate, targeting home favorites and an OVER. For the Orioles-Guardians matchup, the Guardians are 10-9 overall (4-2 at home) after a 2-4 road trip, while the Orioles are .500 (3-3 on the road) following a three-game winning streak that ended with two losses.

Pitching analysis highlights Shane Baz for Baltimore and Parker Messick for Cleveland, who has recorded three wins with one run allowed in 17.2 innings. In the Astros-Rockies game, Houston (7-2 at home) seeks a sweep after winning the first two meetings, while Colorado (2-10 on the road) has lost six straight games.

The Mariners-Padres game features Luis Castillo for Seattle, who has allowed seven runs in his last start against the Astros, against Walker Buehler for San Diego, who threw six shutout innings in his last outing. The author expects a high-scoring game between Seattle and San Diego

The Cleveland Guardians (11-9, second in the AL Central) will host the Baltimore Orioles (9-10, third in the AL East) on Friday at 6:10 p.m. EDT in Cleveland to extend...