Prediction: St. Louis Cardinals VS Milwaukee Brewers 2025-06-14

The St. Louis Cardinals are looking to pull off an upset against their division rivals, the Milwaukee Brewers, on Saturday, June 14th, 2025, at American Family Field. The Brewers are favored to win with odds of -162, while the Cardinals are sitting at +136.

The Brewers have been on a roll as favorites, going 23-11 in 34 games this season. Their ace, Jose Quintana, will take the mound against the Cardinals' Andre Pallante. Quintana and company have a respectable 3.81 team ERA, ranking 14th in MLB.

Meanwhile, the Cardinals have struggled as underdogs, winning only 3 of 8 games when favored by +136 or more. Their offense has been led by Brendan Donovan, who boasts a team-best .310 batting average. However, their pitching staff has a 3.98 ERA, ranking 17th in the league.

The historical underdog win rates in baseball sit at around 41%. However, given the Brewers' strong record as favorites and the Cardinals' struggles as underdogs, I'd argue that the odds are fairly accurate.

The total for this matchup is sitting at 8.0 or 8.5 across various bookmakers, with the Over and Under having relatively similar odds.

Based on the data, I'd recommend taking the Milwaukee Brewers on the moneyline (-162) as the best bet. The Brewers have shown a tendency to perform well as favorites, and their pitching staff has been solid this season.

Best bet: Milwaukee Brewers -162.

Keep in mind that these are just predictions and that upsets can and do happen. Make sure to do your own research and consider other factors before making a wager.

Game details:
- Date: Saturday, June 14th, 2025
- Time: 4:10 p.m. ET
- Location: American Family Field
- TV: Fox Sports1, FDSWI, FDSMW
- Streaming: Fubo

Key players: Jose Quintana (Brewers), Andre Pallante (Cardinals), Christian Yelich (Brewers), Brendan Donovan (Cardinals)

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